circRNA basic information
circBase ID: -
Name: hsa_circ_UHRF1
Synonym: circUHRF1
Host Gene: hsa-miR-1306-5p
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PDAC cell lines (AsPC-1, PANC1, SW1990, BxPC3, Hs766T), human pancreatic normal epithelial cell line (HPDE), HEK-293 T
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1306-5p
Biological function: CircUHRF1 knockdown influenced PDAC cell proliferation, apoptosis, migration and EMT level_n vitro, and tumor growth_n vivo.
Molecular mechanism: circUHRF1 regulated ARL4C expression to promote PDAC progression through sponging hsa-miR-1306-5p.
Survival: -
Supported No.:
 1
Description:

Our results suggest that circUHRF1 is one promising diagnosis or therapeutic target for PDAC management.
Other information
Title:

Identifying a novel IRF3/circUHRF1/miR-1306-5p/ARL4C axis in pancreatic ductal adenocarcinoma progression.

Journal: Cell Cycle
Published: 2022/1/6
PubMed ID: 34983293