circRNA basic information
circBase ID: -
Name: hsa_circ_RNF121
Synonym: CircRNF121
Host Gene: hsa-miR-153-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human endometriosis cell line (End1/E6E7), CC cell lines (Hela, Caski, C33a), adenocarcinoma cell line (HeLa)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-153-3p
Biological function: Knockdown of circRNF121 suppressed cell growth, metastasis, epithelial-mesenchymal transition (EMT), autophagy, and wnt/beta-catenin pathway in CC cells in vitro and blocked tumor formation in vivo.
Molecular mechanism: circRNF121 could affect activating transcription factor 2 (ATF2) expression by decoying hsa-miR-153-3p, thereby accelerating CC cell development.
Survival: -
Supported No.:
 3
Description:

circRNF121 exerted the tumor-suppressive role in CC progression by altering miR-153-3p/ATF2 axis. These results suggested that circRNF121 might be a possible circ-targeted therapy for patients with CC.
Other information
Title:

CircRNF121 knockdown suppresses the progression of cervical cancer by regulating miR-153-3p/ATF2 axis and wnt/beta-catenin pathway.

Journal: Drug Dev Res
Published: 2022/1/5
PubMed ID: 34981843