circRNA basic information
circBase ID: -
Name: hsa_circ_CCDC66
Synonym: CircCCDC66
Host Gene: hsa-miR-3622b-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-3622b-5p
Biological function: CircCCDC66 overexpression inhibited proliferation and promoted apoptosis of chondrocytes and increased IL-6 and TNF-alpha levels in chondrocytes.
Molecular mechanism: hsa-miR-3622b-5p was predicted to be a downstream target gene of circCCDC66, and circCCDC66 overexpression inhibited hsa-miR-3622b-5p expression in chondrocytes._ircCCDC66 overexpression enhanced SIRT3 expression in chondrocytes, while hsa-miR-3622b-5p overexpression inhibited SIRT3 expression in chondrocytes.
Survival: -
Supported No.:
 1
Description:

CircCCDC66 promoted OA chondrocyte apoptosis by regulating the miR-3622b-5p/SIRT3 axis..
Other information
Title:

Circular RNA CCDC66 Regulates Osteoarthritis Progression by Targeting miR-3622b-5p.

Journal: Gerontology
Published: 2022/1/4
PubMed ID: 34979511