circRNA basic information
circBase ID: hsa_circ_0000652
Name: hsa_circ_IQGAP1
Synonym: circ_0000652
Host Gene: hsa-miR-1179
 
 
 
Disease basic information
DO ID:
 7147
DO name: ankylosing spondylitis
Disease details: ankylosing spondylitis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human cell lines (THP-1, Jurkat T)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1179
Biological function: hsa_circ_0000652 promoted proliferation and cytokine production in macrophages and inhibited apoptosis.
Molecular mechanism: hsa_circ_0000652 acted as a competing endogenous RNA (ceRNA) by binding with hsa-miR-1179 and regulated OX40L, hsa_circ_0000652 aggravated the inflammation in the coculture system containing CD4+ T cells and macrophages via OX40/OX40L interaction
Survival: -
Supported No.:
 1
Description:

hsa_circ_0000652 was upregulated in AS patients and may serve as a pro-inflammatory factor in macrophages and a positive regulator of OX40/OX40L by sponging hsa-miR-1179.
Other information
Title:

Hsa_circ_0000652 Aggravates Inflammation by Activation of Macrophages and Enhancement of OX40/OX40L Interaction in Ankylosing Spondylitis.

Journal: Front Cell Dev Biol
Published: 2022/1/4
PubMed ID: 34977002