circRNA basic information
circBase ID: hsa_circ_0001400
Name: -
Synonym: circRNA_0001400
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human cervical cancer SiHa cells, HeLa cells, VK2/E6E7
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-326
Biological function: We found that hsa_circRNA_0001400_siRNA significantly promoted the apoptosis of cervical cancer cells and arrested the cell cycle and migration of cervical cancer cells.
Molecular mechanism: hsa_circRNA_0001400_siRNA can inhibit the protein expression of Akt and that the inhibition of hsa-miR-326 could rescue the inhibition of Akt in cervical cancer cells.
Survival: -
Supported No.:
 1
Description:

In conclusion, this study provides evidence that the hsa_circRNA_0001400-miR-326-Akt network promotes cervical cancer progression. Notably, our findings demonstrate the novel antitumor effects of hsa_circRNA_0001400_siRNA in cervical cancer.
Other information
Title:

Downregulation of hsa_circRNA_0001400 Helps to Promote Cell Apoptosis Through Disruption of the circRNA_0001400-miR-326 Sponge in Cervical Cancer Cells.

Journal: Front Genet
Published: 2022/1/4
PubMed ID: 34976014