circRNA basic information
circBase ID: -
Name: hsa_circ_PTK2
Synonym: circPTK2
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CRC cell lines (HT-29, LoVo, SW480, HCT116), normal colonic epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-136-5p
Biological function: circPTK2 promotes colorectal cancer proliferation, migration, invasion and chemoresistance
Molecular mechanism: hsa-miR-136-5p was bound with circPTK2 and downregulated in CRC.YTHDF1 was targeted via hsa-miR-136-5p and upregulated in CRC samples and cells.
Survival: -
Supported No.:
 4
Description:

circPTK2 interference suppressed CRC proliferation, migration, invasion and chemoresistance via regulating miR-136-5p and YTHDF1.
Other information
Title:

Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance.

Journal: Bioengineered
Published: 2022/1/4
PubMed ID: 34974791