circRNA basic information
circBase ID: -
Name: hsa_circ_RTN4IP1
Synonym: CircRTN4IP1
Host Gene: hsa-miR-541-5p
 
 
 
Disease basic information
DO ID:
 4928
DO name: intrahepatic cholangiocarcinoma
Disease details: intrahepatic cholangiocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: ICC cell lines (HuCC-T1, HuH-28, HCCC-9810, RBE), human_ntrahepatic bile duct_pithelial cells (HIBEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-541-5p
Biological function: Knockdown of circRTN4IP1 led to repression of cell proliferation and glucose metabolism, but promotion of cell apoptosis; however, circRTN4IP1 overexpression had opposite effects.
Molecular mechanism: circRTN4IP1 acted as a sponge for hsa-miR-541-5p, which was found to target HIF1A. hsa-miR-541-5p inhibitors could remit circRTN4IP1 knockdown-mediated action. Also, HIF1A participated in the regulation of hsa-miR-541-5p in ICC progression. In support, circRTN4IP1 depletion impeded tumor formation in vivo.
Survival: -
Supported No.:
 1
Description:

CircRTN4IP1 knockdown inhibited ICC cell malignancy by miR-541-5p/HIF1A axis, providing us with a reliable target for the therapy of ICC.
Other information
Title:

CircRTN4IP1 regulates the malignant progression of intrahepatic cholangiocarcinoma by sponging miR-541-5p to induce HIF1A production.

Journal: Pathol Res Pract
Published: 2022/1/3
PubMed ID: 34974242