circRNA basic information
circBase ID: hsa_circ_0091579
Name: -
Synonym: Circ_0091579
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: THLE-2, HCC cell lines (HCCLM3, MHCC97H, Huh-7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-136-5p
Biological function: Circ_0091579 knockdown suppressed the proliferation, migration, invasion, cell cycle progression and epithelial-mesenchymal transition (EMT) and induced apoptosis of HCC cells.
Molecular mechanism: Circ_0091579 acted as a molecular sponge for hsa-miR-136-5p, and circ_0091579 silencing-mediated effects were largely overturned by the knockdown of hsa-miR-136-5p in HCC cells. hsa-miR-136-5p interacted with the 3 untranslated region (3UTR) of TRIM27, and TRIM27 overexpression largely counteracted hsa-miR-136-5p overexpression-induced influences in HCC cells. Circ_0091579 sponged hsa-miR-136-5p to up-regulate TRIM27 expression in HCC cells.
Survival: poor
Supported No.:
 6
Description:

Circ_0091579 exhibited an oncogenic role to enhance the malignant potential of HCC cells through mediating miR-136-5p/TRIM27 axis in vitro and in vivo.
Other information
Title:

Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27.

Journal: Biomed J
Published: 2022/1/3
PubMed ID: 34974169