circRNA basic information
circBase ID: hsa_circ_0005320
Name: -
Synonym: Circ_0005320
Host Gene: hsa-miR-486-3p, hsa-miR-637
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human OSCC cell lines (CAL27, HSC-2, SCC25), human oral keratinocyte cells (HOK)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-486-3p, hsa-miR-637
Biological function: Knockdown of circ_0005320 suppressed OSCC cell growth, migration, invasion, and induced cell apoptosis in vitro, as well as impeded tumor growth in vivo.
Molecular mechanism: Mechanistically, hsa-miR-486-3p or hsa-miR-637 were confirmed to be a target of circ_0005320. Moreover, the inhibitory effects of circ_0005320 silencing on OSCC growth were reversed by the inhibition of hsa-miR-486-3p or hsa-miR-637. We also found that circ_0005320-hsa-miR-486-3p/hsa-miR-637 axis mediated the activation of JAK2/STAT3 pathway.
Survival: -
Supported No.:
 1
Description:

This study revealed a novel regulatory network of circ_0005320-miR-486-3p/miR-637 axis in OSCC progression, suggesting that circ_0005320 might be a potential biomarker and therapeutic target for OSCC.
Other information
Title:

Circ_0005320 promotes oral squamous cell carcinoma tumorigenesis by sponging microRNA-486-3p and microRNA-637.

Journal: Bioengineered
Published: 2021/12/31
PubMed ID: 34967281