circRNA basic information
circBase ID: hsa_circ_0000527
Name: -
Synonym: Circ_0000527
Host Gene: hsa-miR-1236-3p
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal retinal epithelial cell line (ARPE-19), RB cell line (Y79) , RB cell line (SO-Rb50)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1236-3p
Biological function: Circ_0000527 was overexpressed in RB patients and related to advanced TNM stages, optic nerve invasion and choroidal invasion. Circ_0000527 knockdown suppressed cell proliferation, migration, invasion and angiogenesis and promoted apoptosis in RB cells_n vitro.
Molecular mechanism: Circ_0000527 sponged hsa-miR-1236-3p, which directly targeted SMAD2.
Survival: poor
Supported No.:
 5
Description:

Circ_0000527/miR-1236-3p/SMAD2 axis played a positive role in the progression of RB.
Other information
Title:

Circ_0000527 Drives Retinoblastoma Progression by Regulating miR-1236-3p/SMAD2 Pathway.

Journal: Curr Eye Res
Published: 2021/12/30
PubMed ID: 34963405