circRNA basic information
circBase ID: hsa_circ_0002109
Name: -
Synonym: circRNA-0002109
Host Gene: hsa-miR-129-5P
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human glioma cell lines (U87, LN229, U251, SHG44, A172), a normal astrocyte cell line (NHA)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-129-5P
Biological function: Downregulation of circRNA-0002109 expression inhibited the proliferation, migration, and invasion of glioma cells and inhibited the malignant progression of tumors_n vivo.
Molecular mechanism: Investigations into the relevant mechanisms showed that circRNA-0002109 upregulated the expression of EMP2 through endogenous competitive binding of microRNA-129-5P (hsa-miR-129-5P), which partially alleviated the inhibitory effect of hsa-miR-129-5P on epithelial membrane protein-2 (EMP2) and ultimately promoted the malignant development of glioma.
Survival: -
Supported No.:
 1
Description:

Our results indicate that circRNA-0002109 plays an important role in the proliferation, invasion, and migration of glioma cells by regulating the miR-129-5P/EMP2 axis, which provides a new potential therapeutic target for glioma.
Other information
Title:

circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis.

Journal: Mol Ther Nucleic Acids
Published: 2021/12/24
PubMed ID: 34938603