circRNA basic information
circBase ID: hsa_circ_0062270
Name: hsa_circ_CDC45
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1909
DO name: melanoma
Disease details: melanoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: melanoma cell lines (A375, MNT-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: In addition, hsa_circ_0062270 knockdown markedly inhibited the viability, proliferation, invasion and promoted the apoptosis of melanoma cells.
Molecular mechanism: Cell division cycle protein 45 (CDC45) is the host gene of hsa_circ_0062270, and downregulation of hsa_circ_0062270 notably decreased the expression of CDC45 in melanoma cells. Rescue assays confirmed that hsa_circ_0062270 regulated the growth of melanoma cells through CDC45. Moreover, RIP analysis showed that hsa_circ_0062270 interacted with RNA-binding protein (RBP) EIF4A3. Furthermore, in vivo study indicated that knockdown of hsa_circ_0062270 inhibited the melanoma tumor growth in vivo.
Survival: -
Supported No.:
 2
Description:

Downregulation of hsa_circ_0062270 can inhibit the progression of melanoma through downregulation of CDC45.
Other information
Title:

Knockdown of circular RNA hsa_circ_0062270 suppresses the progression of melanoma via downregulation of CDC45.

Journal: Histol Histopathol
Published: 2021/12/22
PubMed ID: 34931691