circRNA basic information
circBase ID: -
Name: hsa_circ_MTO1
Synonym: CircMTO1
Host Gene: hsa-miR-541-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: HCC cell lines (SK-Hep1, SMMC-7721, HepG2), HEK293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-541-5p
Biological function: The results depicted that silencing circMTO1 or upregulating miR-541-5p expression facilitated HCC cell proliferation, migration, and invasion and inhibited apoptosis. CircMTO1 silencing upregulated the expression of downstream ZIC1 regulators of the Wnt/beta-catenin pathway markers, beta-catenin, cyclin D1, c-myc, and the mesenchymal markers N-cadherin, Vimentin, and MMP2, while the epithelial marker E-cadherin was downregulated.
Molecular mechanism: CircMTO1 acted as a miRNA sponge of hsa-miR-541-5p in HCC, hsa-miR-541-5p knockdown had the opposite effect and reversed the effect of circMTO1 silencing on the regulation of downstream ZIC1 regulators. Intratumoral injection of hsa-miR-541-5p inhibitor suppressed tumor growth and reversed the effect of circMTO1 silencing on the promotion of tumor growth in HCC.
Survival: -
Supported No.:
 3
Description:

These findings indicated that circMTO1 suppressed HCC progression via the circMTO1/ miR-541-5p/ZIC1 axis by regulating Wnt/beta-catenin signaling and epithelial-to-mesenchymal transition, making it a novel therapeutic target.
Other information
Title:

CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/beta-catenin signaling pathway and epithelial-to-mesenchymal transition.

Journal: Cell Death Dis
Published: 2021/12/22
PubMed ID: 34930906