circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: CircPVT1
Host Gene: hsa-miR-195
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: PTC cell lines (K1, IHH-4, BCPAP, TPC-1), human thyroid follicular epithelial cells (Nthy-ori 3_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-195
Biological function: After downregulating_ircPVT1_xpression in PTC cells, the abilities of cell proliferation, migration, and invasion were obviously suppressed, and the Wnt/beta-catenin signaling pathway was also repressed.
Molecular mechanism: hsa-miR-195_ould both bind to_VT1_nd_EGFA, while_VT1_ould promote the expression of_EGFA_y binding to_iR-195. Downregulation of_EGFA_xpression in PTC cells revealed weakened cell proliferation, migration, and invasion capacities, and restrained Wnt/beta-catenin signaling pathway. Therefore, we demonstrated that_ircPVT1_ould promote_EGFA_xpression by sponging_iR-195.
Survival: -
Supported No.:
 2
Description:

CircPVT1_ould serve as a molecule sponge for_iR-195_nd mediate the ceRNA network to promote the expression of_EGFA, thus contributed to the malignant progression of PTC.
Other information
Title:

Circular RNA Pvt1 oncogene (CircPVT1) promotes the progression of papillary thyroid carcinoma by activating the Wnt/beta-catenin signaling pathway and modulating the ratio of microRNA-195 (miR-195) to vascular endothelial growth factor A (VEGFA) expression.

Journal: Bioengineered
Published: 2021/12/21
PubMed ID: 34927541