circRNA basic information
circBase ID: -
Name: hsa_circ_RHOT1
Synonym: circRHOT1
Host Gene: hsa-miR-3666
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: Bladder cancer cell lines (253J, BT-B, HTB9, HT-1376, 5637, T24, UMUC3), normal human bladder cell (SV-HUC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-3666
Biological function: circRHOT1 knockdown could markedly suppress BC cell proliferation and migration level and could aggravate the sensitivity of BC cells to NK cells.
Molecular mechanism: circRHOT1 expression in BC cells could be regulated by ZNF652, and circRHOT1 could promote SMAD5 expression to regulate BC cell cellular progression by sponging hsa-miR-3666.
Survival: -
Supported No.:
 1
Description:

These results may provide a new direction for developing novel diagnostic or therapeutic targets for BC.
Other information
Title:

ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in Bladder Cancer via Targeting miR-3666.

Journal: J Immunol Res
Published: 2021/12/21
PubMed ID: 34926705