circRNA basic information
circBase ID: -
Name: hsa_circ_LDLR
Synonym: CircLDLR
Host Gene: hsa-miR-637
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: TPC-1, IHH-4
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-637
Biological function: circLDLR was found to be markedly upregulated in PTC tissues and cell lines, and knockdown of circLDLR inhibited PTC cell proliferation, migration, and invasion but induced apoptosis_n vitro.
Molecular mechanism: circLDLR acted as a sponge for hsa-miR-637, and hsa-miR-637 interference reversed the anticancer effects of circLDLR knockdown on PTC cells. LMO4 was verified to be a target of hsa-miR-637, LMO4 upregulation abolished hsa-miR-637 mediated inhibition of cell growth and metastasis in PTC. Additionally, circLDLR could indirectly modulate LMO4 via acting as a sponge of hsa-miR-637 in PTC cells. Besides that, xenograft analysis showed that circLDLR knockdown suppressed tumor growth_n vivo_ia regulating LMO4 and hsa-miR-637.
Survival: poor
Supported No.:
 3
Description:

Taken together, these results demonstrated that circLDLR promoted PTC tumorigenesis through miR-637/LMO4 axis, which may provide a novel insight into the understanding of PTC tumorigenesis and be useful in developing potential targets for PTC treatment.
Other information
Title:

CircLDLR Promotes Papillary Thyroid Carcinoma Tumorigenicity by Regulating miR-637/LMO4 Axis.

Journal: Dis Markers
Published: 2021/12/21
PubMed ID: 34925640