circRNA basic information
circBase ID: -
Name: hsa_circ_IL4R
Synonym: CircIL4R
Host Gene: hsa-miR-761
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal colorectal epithelial cell line (FHC), human CRC cell lines (HCT116, DLD1, LoVo, SW620, HT29, SW480)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-761
Biological function: Functional experiments demonstrated that circIL4R promotes CRC cell proliferation, migration, and invasion via the PI3K/AKT signaling pathway.
Molecular mechanism: Mechanistically, circIL4R was regulated by TFAP2C and competitively interacted with hsa-miR-761 to enhance the expression of TRIM29, thereby targeting PHLPP1 for ubiquitin-mediated degradation to activate the PI3K/AKT signaling pathway and consequently facilitate CRC progression.
Survival: poor
Supported No.:
 1
Description:

Our findings demonstrate that upregulation of circIL4R plays an oncogenic role in CRC progression and may serve as a promising diagnostic and prognostic biomarker for CRC detection and as a potential therapeutic target for CRC treatment.
Other information
Title:

CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer.

Journal: Mol Cancer
Published: 2021/12/20
PubMed ID: 34922544