circRNA basic information
circBase ID: -
Name: hsa_circ_LPAR3
Synonym: Circ_LPAR3
Host Gene: hsa-miR-513b-5p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OSCC cell lines (CAL27,SCC9, UM1, HSC6), human normal oral keratinocytes (HOK)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-513b-5p
Biological function: circ_LPAR3 was upregulated in OSCC. Its knockdown in cells could decrease cell survival and mobility and in mice model, could inhibit the tumor growth and angiogenesis.
Molecular mechanism: Circ_LPAR3 promoted VEGFC and AKT1 activity by sponging hsa-miR-513b-5p in OSCC cells.
Survival: poor
Supported No.:
 3
Description:

Knockdown of circ_LPAR3 could inhibit the OSCC progression by sponging miR-513b-5p and activating VEGFC and AKT1.
Other information
Title:

Circ_LPAR3 promotes the progression of oral squamous cell carcinoma (OSCC).

Journal: Biochem Biophys Res Commun
Published: 2021/12/19
PubMed ID: 34922206