circRNA basic information
circBase ID: hsa_circ_0014235
Name: -
Synonym: Circ_0014235
Host Gene: hsa-miR-146b-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: normal NSCLC cell lines (PC9, HCC827)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-146b-5p
Biological function: circ_0014235 was highly expressed in Gefitinib-resistant NSCLC cells. Circ_0014235 downregulation reduced Gefitinib IC50, inhibited cell proliferation and induced cell apoptosis and cell cycle arrest in Gefitinib-resistant NSCLC cells, while these effects were reversed by the inhibition of miR-146b-5p, a target of circ_0014235.
Molecular mechanism: YAP was a target gene of hsa-miR-146b-5p, and circ_0014235 relieved hsa-miR-146b-5p-mediated inhibition on YAP by targeting hsa-miR-146b-5p. hsa-miR-146b-5p restoration-blocked Gefitinib IC50 and cell malignant behaviors were recovered by YAP overexpression. YAP positively regulated PD-L1 expression, and YAP overexpression contributes to Gefitinib IC50 and cell malignant behaviors by upregulating PD-L1.
Survival: -
Supported No.:
 2
Description:

Circ_0014235 confers Gefitinib resistance and malignant behaviors in Gefitinib-resistant NSCLC by governing the miR-146b-5p/YAP/PD-L1 pathway.
Other information
Title:

Circ_0014235 confers Gefitinib resistance and malignant behaviors in non-small cell lung cancer resistant to Gefitinib by governing the miR-146b-5p/YAP/PD-L1 pathway.

Journal: Cell Cycle
Published: 2021/12/18
PubMed ID: 34919024