circRNA basic information
circBase ID: -
Name: hsa_circ_GOT1
Synonym: CircGOT1
Host Gene: hsa-miR-606
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: ESCC cell lines (KYSE150, KYSE510, TE1, TE5, TE13), human normal esophageal epithelial cells (HEEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-606
Biological function: We identified that circGOT1 and GOT1 upregulate, whereas miR-606 was reduced in ESCC tissues and cell lines. High circGOT1 and GOT1 expression associated with poor survival and worse prognosis of ESCC patients, but miR-606 revealed opposite traits.
Molecular mechanism: Mechanically, circGOT1 sponged hsa-miR-606 to promote GOT1, which induced cell proliferation, migration, aerobic glycolysis, and cisplatin resistance. The tumor growth was reduced by circGOT1 inhibition in xenograft mouse.
Survival: poor
Supported No.:
 1
Description:

Our results indicate the oncogene role of circGOT1 in ESCC via an endogenous competition RNA (ceRNA) mechanism to promote GOT1 expression via sponging miR-606.
Other information
Title:

CircGOT1 promotes cell proliferation, mobility, and glycolysis-mediated cisplatin resistance via inhibiting its host gene GOT1 in esophageal squamous cell cancer.

Journal: Cell Cycle
Published: 2021/12/18
PubMed ID: 34919012