circRNA basic information
circBase ID: -
Name: mmu_circ_PTK2
Synonym: circPTK2
Host Gene: mmu-miR-29b-3p
 
 
 
Disease basic information
DO ID:
 0040085
DO name: bacterial sepsis
Disease details: Sepsis
Species: mouse
Species details: mouse
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BAK1
Associated microRNA: mmu-miR-29b-3p
Biological function: CircPTK2 silencing relieved the cardiac function and reduced inflammatory reaction and cardiomyocyte apoptosis of septic mice.
Molecular mechanism: circPTK2 competitively bound to miR-29b-3p to upregulate BAK1 mRNA level. Inhibition of miR-29b-3p and BAK1 overexpression could counteract the protective role of circPTK2 silencing in the myocardium of septic mice.
Survival: -
Supported No.:
 1
Description:

CircPTK2 competitively bound to miR-29b-3p to upregulate BAK1 mRNA level, to promote cardiomyocyte apoptosis, inflammatory response, and myocardial damage of the myocardium of septic mice.
Other information
Title:

CircRNAPTK2 Promotes Cardiomyocyte Apoptosis in Septic Mice by Competitively Binding to miR-29b-3p with BAK1.

Journal: Int Arch Allergy Immunol
Published: 2021/12/17
PubMed ID: 34915498