circRNA basic information
circBase ID: hsa_circ_0040823
Name: -
Synonym: circ_0040823
Host Gene: hsa-miR-516b
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: leukemia cell lines (HL60, THP-1, U937, KG-1), human bone marrow stromal cell line (HS-5)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-516b
Biological function: Overexpression of circ_0040823 inhibited AML cell proliferation, and induced apoptosis and cell cycle arrest. Upregulation of circ_0040823 also repressed the growth of xenograft tumors in vivo.
Molecular mechanism: circ_0040823 acted as a hsa-miR-516b sponge and regulated key cellular events in leukemia cells via downregulating hsa-miR-516b. Moreover, tumor suppressor phosphatase and tensin homolog (PTEN) was a downstream target of hsa-miR-516b. The inhibition of hsa-miR-516b impaired the proliferation capacity of leukemia cells and induced apoptosis, while PTEN deficiency attenuated these effects.
Survival: -
Supported No.:
 1
Description:

This study showed that circ_0040823 inhibited proliferation and induced apoptosis of AML cells by sponging miR-516b, thereby diminishing the regulatory effect of miR-516b on PTEN. These findings identified circ_0040823/miR-516b/PTEN as a new therapeutic target for AML.
Other information
Title:

Circular RNA circ_0040823 inhibits the proliferation of acute myeloid leukemia cells and induces apoptosis by regulating miR-516b/PTEN.

Journal: J Gene Med
Published: 2021/12/17
PubMed ID: 34913223