circRNA basic information
circBase ID: hsa_circ_0044556
Name: -
Synonym: CircRNA_0044556
Host Gene: hsa-miR-145
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal mammary epithelial cell line (MCF-10A), TNBC cell lines (MDA-MB-231, MDA-MB-453, MDA-MB-157, BT549), ADM-resistant cell line (MDA-MB-231/ADM)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-145
Biological function: CircRNA_0044556 regulates the viability of ADM-treated MDA-MB-231 and MDA-MB-231/ADM cells,CircRNA_0044556 affects the apoptotic and migratory capacities of TNBC cells with or without ADM treatment
Molecular mechanism: CircRNA_0044556 sponges hsa-miR-145, which is expressed at a low level in TNBC tissues and TNBC cells with or without ADM treatment, Overexpressed circRNA_0044556 attenuates apoptosis and enhances migration of TNBC cells with or without ADM treatment by targeting hsa-miR-145, hsa-miR-145 targets NRAS, which is overexpressed in TNBC tissues and cells with or without ADM treatment
Survival: -
Supported No.:
 1
Description:

CircRNA_0044556 was negatively correlated with miR_145 yet positively correlated with NRAS, the target gene of miR_145, in addition to the discovery suggesting the negative regulatory effects of circRNA_0044556 on miR_145. CircRNA_0044556 diminished the sensitivity of TNBC cells to ADM via the miR_145/NRAS axis.
Other information
Title:

CircRNA_0044556 diminishes the sensitivity of triple_negative breast cancer cells to adriamycin by sponging miR_145 and regulating NRAS.

Journal: Mol Med Rep
Published: 2021/12/17
PubMed ID: 34913063