circRNA basic information
circBase ID: -
Name: hsa_circ_LRRC7
Synonym: CircularLRRC7
Host Gene: hsa-miR-1281
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1281
Biological function: hsa_circ_0114014 (circLRRC7) was dramatically down-regulated in GBM when compared with normal brain tissues (p< 0.0001).
Molecular mechanism: Analyses of the predicted target miRNAs of circLRRC7 in CSCD and CRI databases, in combination with the miRNA expression data in GBMs and normal brains from GSE database, revealed hsa-miR-1281 as a potential downstream target of circLRRC7. Subsequently, the target genes of hsa-miR-1281 were predicted by TargetScan, miRDB and miRNATAR databases. Intersection analysis and correlation test indicated that PDXP was a potential target of hsa-miR-1281.
Survival: poor
Supported No.:
 1
Description:

In summary, circLRRC7 may be a tumor suppressor that associated with miR-1281 and PDXP expression in GBM, which may provide novel therapeutic targets for GBM treatment.
Other information
Title:

CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma.

Journal: Front Mol Biosci
Published: 2021/12/17
PubMed ID: 34912844