circRNA basic information
circBase ID: -
Name: -
Synonym: cricRNAs
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1561
DO name: cognitive disorder
Disease details: cognitive impairment
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Compared with the control group, there were 5 significantly up-regulated circRNA and 3 down-regulated circRNA in the WMH with cognitive impairment group; 8 circRNA were significantly up-regulated and 2 were down-regulated in the WMH without cognitive impairment group. When compared with the WMH with cognitive impairment group, no co-differentially expressed circRNA was found in WMH without cognitive impairment group and control group. Compared with the control group, the expression of hsa_circ_0092222 was up-regulated and the expressions of hsa_circ_0000662 and hsa_circ_0083773 were down-regulated in the WMH with cognitive impairment group and the WMH without cognitive impairment group, and there was no significant difference between the 2 groups (all_>0.05).
Molecular mechanism: Two target miRNA (hsa-miR-19a-3p and hsa-miR-19b-3p) of hsa_circ_0092222 were predicted, and the target gene was ribosomal protein S4, Y-linked 1 (RPS4Y1). Hsa_circ_0000662 predicted a target miRNA (hsa-miR-194) with axis inhibitor 1 (AXIN1) as the target gene. Hsa_circ_0083773 predicted 7 target miRNA, and the target gene was recombinant scavenger receptor class A member 3 (SCARA3).
Survival: -
Supported No.:
 1
Description:

The circRNA expression profile of patients with WMH is changed significantly. The differentially expressed circRNA may be the cause of WMH; Hsa_circ_0092222, hsa_circ_0000662, and hsa_circ_0083773 may regulate the expression of target genes by targeting adsorption of the target miRNA, leading to brain white matter damage through Janus kinase 2 (JAK2)/signal transducers and activators of transcription (STAT3) signal pathway and Wnt signal pathway.There is no significant difference in circRNA expression profile between WMH with or without cognitive impairment. Cognitive impairment in patients with WMH may have other reasons.
Other information
Title:

Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment.

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban
Published: 2021/12/17
PubMed ID: 34911837