circRNA basic information
circBase ID: -
Name: hsa_circ_DLG1
Synonym: circDLG1
Host Gene: hsa-miR-141-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human gastric cancer cell lines (HGC27, BGC823, MKN45, MKN28, SGC7901, AGS), normal gastric epithelial cell line GES-1, murine gastric cancer cell line MFC, human embryonic kidney (HEK) 293_T
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-141-3p
Biological function: circDLG1 was significantly upregulated in distant metastatic lesions and gastric cancer tissues resistant to anti-PD-1 therapy and was associated with an aggressive tumor phenotype and adverse prognosis in gastric cancer patients treated with anti-PD-1 therapy. Ectopic circDLG1 expression promoted the proliferation, migration, invasion, and immune evasion of gastric cancer cells.
Molecular mechanism: circDLG1 interacted with hsa-miR-141-3p and acted as a miRNA sponge to increase the expression of CXCL12, which promoted gastric cancer progression and resistance to anti-PD-1-based therapy.
Survival: -
Supported No.:
 1
Description:

Overall, our findings demonstrate how circDLG1 promotes gastric cancer cell proliferation, migration, invasion and immune evasion and provide a new perspective on the role of circRNAs during gastric cancer progression.
Other information
Title:

The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p.

Journal: Mol Cancer
Published: 2021/12/17
PubMed ID: 34911533