circRNA basic information
circBase ID: -
Name: hsa_circ_SEC24A
Synonym: CircSEC24A
Host Gene: hsa-miR-606
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal pancreatic duct epithelial cell line (HPDE), 4 types of pancreatic cancer cell lines (PANC-1, MIA PaCa-2, SW1990, BxPC-3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-606
Biological function: knockdown of circSEC24A significantly inhibited the proliferative, migration and invasive capacity of pancreatic cancer cells, whereas miR-606 inhibitor obviously counteracted these effects.
Molecular mechanism: Further study confirmed that circSEC24A alleviated suppression on target TGFBR2 expression by directly sponging hsa-miR-606 and then influenced the tumorigenesis of pancreatic cancer.
Survival: -
Supported No.:
 1
Description:

These findings indicated that the progression of pancreatic cancer can be driven by circSEC24A influencing miR-606/TGFBR2 axis. Therefore, circSEC24A might be used as a critical biomarker influencing the early diagnosis and prognosis of pancreatic cancer.
Other information
Title:

CircSEC24A upregulates TGFBR2 expression to accelerate pancreatic cancer proliferation and migration via sponging to miR-606.

Journal: Cancer Cell Int
Published: 2021/12/16
PubMed ID: 34906151