circRNA basic information
circBase ID: -
Name: hsa_circ_DPP4
Synonym: circDPP4
Host Gene: hsa-miR-564
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal prostate epithelial cell line (RWPE-1) , four PC cell lines (PC3, DU145, LNCaP, PC-3M)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-564
Biological function: Decreasing circDPP4 suppresses cell proliferation, colony formation, migration/invasion, and 50% inhibitory concentration of DTX in PC cells, and promotes the apoptosis rate.
Molecular mechanism: Both overexpressing hsa-miR-564 and inhibiting ZIC2 could imitate those effects, whereas inhibiting hsa-miR-564 and restoring ZIC2 could separately counteract them. Mechanistically, circDPP4 functions as a hsa-miR-564 sponge and regulates the expression of ZIC2, a target gene for hsa-miR-564. Tumor growth is retarded by silencing circDPP4, accompanied by elevated hsa-miR-564 and attenuated Ki-67 and ZIC2.
Survival: poor
Supported No.:
 3
Description:

Blocking circDPP4 antagonizes cell progression of PC and contributes to in vitro DTX cytotoxicity via regulating the miR-564/ZIC2 axis, at least. The present study suggests that circDPP4 is a potential biomarker and target for PC.
Other information
Title:

Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating the miR-564/ZIC2 axis.

Journal: J Gene Med
Published: 2021/12/15
PubMed ID: 34904327