circRNA basic information
circBase ID: -
Name: hsa_circ_PSEN1
Synonym: circ-PSEN1
Host Gene: hsa-miR-200b-3p
 
 
 
Disease basic information
DO ID:
 8947
DO name: diabetic retinopathy
Disease details: diabetic retinopathy
Species: human
Species details: human
Sample type: cell line
Sample type details: retinal pigment epithelial cell line-19
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-200b-3p
Biological function: Inhibition of circ-PSEN1 in ARPE19 cells ameliorated the ferroptosis induced by HG was ameliorated, as evidenced by changes in the ferroptosis-related biomarkers/genes and decreased cell death.
Molecular mechanism: circ-PSEN1 acted as a sponge for hsa-miR-200b-3p. Inhibition of hsa-miR-200b-3p partially reversed the effects of circ-PSEN1 on ferroptosis. Furthermore, cofilin-2 (CFL2) was the target gene of hsa-miR-200b-3p, and it abrogated the inhibitory effect of hsa-miR-200b-3p on ferroptosis.
Survival: -
Supported No.:
 1
Description:

knockdown of circ-PSEN1 can mitigate ferroptosis of ARPE19 cells induced by HG via the miR-200b-3p/CFL2 axis.
Other information
Title:

Downregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis.

Journal: Bioengineered
Published: 2021/12/15
PubMed ID: 34903141