circRNA basic information
circBase ID: -
Name: mmu_circ_Zc3h4
Synonym: circZc3h4
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1100
DO name: ovarian disease
Disease details: ovary and uterus damage
Species: mouse
Species details: mouse
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Both in vivo and in vitro, PCM caused dose-dependent damages to the ovaries and uteri, increased their circRNA Scar levels and decreased circZc3h4 abundance.
Molecular mechanism: all UPR signaling pathways in the low-dose group and some in the middle-dose group were activated.
Survival: -
Supported No.:
 1
Description:

It is speculated that UPR may antagonize the partial ovarian and uterine damage in adolescent mice induced by PCM at doses less than NOAEL via changes in circZc3h4 and circRNA Scar.
Other information
Title:

Combined effect of unfolded protein response and circZc3h4, circRNA Scar in mouse ovary and uterus damage induced by procymidone.

Journal: Ecotoxicol Environ Saf
Published: 2021/12/14
PubMed ID: 34902777