circRNA basic information
circBase ID: -
Name: hsa_circ_RAB31
Synonym: circRAB31
Host Gene: hsa-miR-885-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human embryonic kidney cell line (HEK293T), GC cell lines (AGS, MGC803, MKN45, BGC823), a normal human gastric epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-885-5p
Biological function: Overexpression of circRAB31 suppressed gastric cancer proliferation and metastasis_n vitro_nd_n vivo, whereas silencing of circRAB31 had the opposite effects.
Molecular mechanism: Bioinformatic analysis as well as pull-down and luciferase assays revealed that circRAB31 exerted tumor-suppressive functions by binding directly to hsa-miR-885-5p. In addition, we demonstrated that circRAB31 could suppress PI3K/AKT signaling via the phosphatase and tensin homologue (PTEN)-a downstream target gene of hsa-miR-885-5p.
Survival: -
Supported No.:
 1
Description:

Our results demonstrated that circRAB31 could serve as a sponge of miR-885-5p to regulate gastric cancer cell proliferation, migration, and invasion by affecting the PTEN/PI3K/AKT signaling.
Other information
Title:

Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway.

Journal: Mol Ther Oncolytics
Published: 2021/12/14
PubMed ID: 34901392