circRNA basic information
circBase ID: -
Name: hsa_circ_HUWE1
Synonym: circHUWE1
Host Gene: hsa-miR-34a-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cells (549, H1299), cisplatin resistant cells (A549/DDP, H1299/DDP), control lung epithelial cells (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-34a-5p
Biological function: circHUWE1 downregulation inhibited DDP resistance, proliferation, migration, and invasion while it induced apoptosis and cell cycle arrest of DDP-resistant NSCLC cells, which was overturned by silencing of miR-34a-5p.
Molecular mechanism: TNFAIP8 was a functional gene of hsa-miR-34a-5p, and the suppressive effects of hsa-miR-34a-5p overexpression on DDP-resistant NSCLC progression were dependent on the suppression of TNFAIP8. circHUWE1 inhibition also delayed tumor growth of DDP-resistant NSCLC cells.
Survival: -
Supported No.:
 2
Description:

circHUWE1 functioned as a promoter in DDP-resistant NSCLC by interaction with miR-34a-5p-TNFAIP8 networks, providing novel insight into DDP-resistant NSCLC diagnosis and treatment.
Other information
Title:

circHUWE1 Exerts an Oncogenic Role in Inducing DDP-Resistant NSCLC Progression Depending on the Regulation of miR-34a-5p/TNFAIP8.

Journal: Int J Genomics
Published: 2021/12/14
PubMed ID: 34901263