circRNA basic information
circBase ID: -
Name: hsa_circ_RNF13
Synonym: CircRNF13
Host Gene: hsa-miR-139-5p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal pancreatic duct epithelial cell line (HPDE), different PC cell lines (PANC-1, MIA-PaCa-2, SW1990, BxPC-3, AsPC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-139-5p
Biological function: CircRNF13 was overexpressed in PC cell lines compared with the normal pancreatic duct cell line. Additionally, inhibition of circRNF13 impaired the proliferation, migration, and invasion of PC cells.
Molecular mechanism: CircRNF13 could serve as the molecular sponge of hsa-miR-139-5p to inhibit its association with IGF1R that eventually accelerated the malignant progression of PC.
Survival: -
Supported No.:
 2
Description:

CircRNF13 serves as a competitive endogenous RNA of IGF1R to inhibit the function of miR-139-5p that eventually reinforces the malignant phenotype of PC.
Other information
Title:

CircRNF13 Promotes the Malignant Progression of Pancreatic Cancer through Targeting miR-139-5p/IGF1R Axis.

Journal: J Oncol
Published: 2021/12/14
PubMed ID: 34899908