circRNA basic information
circBase ID: -
Name: hsa_circ_ARVCF
Synonym: CircARVCF
Host Gene: hsa-miR-1205
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal gastric mucosa cells (GES-1), GC cells (N87, HGC-27, MKN-45, AGS)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1205
Biological function: circARVCF silencing inhibited DDP resistance, colony formation and metastasis and induced apoptosis in DDP-resistant GC cells.
Molecular mechanism: CircARVCF directly interacted with hsa-miR-1205 and hsa-miR-1205 inhibition reversed circARVCF silencing-mediated effect on DDP resistance in DDP-resistant GC cells. FGFR1 served as the target gene of hsa-miR-1205. hsa-miR-1205 overexpression restrained the resistance of DDP-resistant GC cells to DDP, but FGFR1 elevation abated the effect. In addition, circARVCF knockdown repressed DDP resistance_n vivo.
Survival: -
Supported No.:
 1
Description:

CircARVCF enhanced DDP resistance in GC by elevating FGFR1 through sponging miR-1205.
Other information
Title:

CircARVCF Contributes to Cisplatin Resistance in Gastric Cancer by Altering miR-1205 and FGFR1.

Journal: Front Genet
Published: 2021/12/14
PubMed ID: 34899853