circRNA basic information
circBase ID: -
Name: hsa_circ_Sirt1
Synonym: circ-Sirt1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0050117
DO name: disease by infectious agent
Disease details: Inflammation
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: RAW264.7 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: LPS reduced Circ-sirt1 mRNA expression by one-third, while TSS started this phenomenon
Molecular mechanism: TSS has an anti-inflammatory function by upregulating circ-Sirt1 and subsequently inhibiting the translocation of NF-kappaB. An in vivo experiment was also performed to confirm the protective function of TSS on inflammation.
Survival: -
Supported No.:
 1
Description:

TSS is a potential treatment for inflammation.
Other information
Title:

Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-Sirt1 and inhibiting the entry of NF-kappaB into the nucleus.

Journal: Eur J Pharmacol
Published: 2021/12/14
PubMed ID: 34896110