circRNA basic information
circBase ID: -
Name: hsa_circ_VMA21
Synonym: CircVMA21
Host Gene: hsa-miR-7-5p
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: sepsis-engendered acute kidney injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human kidney 2 cells (HK-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-7-5p
Biological function: CircVMA21 overexpression reversed the suppressive effect on cell viability and the promotional effects on cell apoptosis, inflammation and oxidative stress in HK2 cells mediated by LPS.
Molecular mechanism: CircVMA21 was identified as the sponge for hsa-miR-7-5p. hsa-miR-7-5p overexpression abrogated the impacts of circVMA21 elevation on cell viability, apoptosis, inflammation and oxidative stress in LPS-stimulated HK2 cells. hsa-miR-7-5p directly targeted PPARA, and hsa-miR-7-5p inhibition ameliorated LPS-induced HK2 cell damage by targeting PPARA.
Survival: -
Supported No.:
 1
Description:

CircVMA21 overexpression alleviated LPS-stimulated HK2 cell damage through the regulation of miR-7-5p/PPARA.
Other information
Title:

CircVMA21 ameliorates lipopolysaccharide (LPS)-induced HK-2 cell injury depending on the regulation of miR-7-5p/PPARA.

Journal: Autoimmunity
Published: 2021/12/14
PubMed ID: 34894921