circRNA basic information
circBase ID: hsa_circ_0000326
Name: -
Synonym: circ_0000326
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bladder epithelial cell line (SV-HUC-1), BC cell lines (BIU-87, 5637, RT-112, T24)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-338-3p
Biological function: circ_0000326 could promote BC cell growth and migration, and inhibit apoptosis.
Molecular mechanism: Dual-luciferase reporter gene assay confirmed that circ_0000326 and ETS1 could bind directly to hsa-miR-338-3p. Furthermore, circ_0000326 sponged hsa-miR-338-3p and up-regulated ETS1 expression. ETS1 was associated with the activation of PI3K/AKT pathway. Moreover, circ_0000326 could activate PI3K/AKT pathway by hsa-miR-338-3p/ETS1 axis.
Survival: -
Supported No.:
 1
Description:

circ_0000326/miR-338-3p/ETS1/PI3K/AKT pathway is involved in regulating BC progression.
Other information
Title:

Circular RNA_0000326 promotes bladder cancer progression via microRNA-338-3p/ETS Proto-Oncogene 1/phosphoinositide-3 kinase/Akt pathway.

Journal: Bioengineered
Published: 2021/12/11
PubMed ID: 34889689