circRNA basic information
circBase ID: -
Name: hsa_circ_CREBBP
Synonym: circCREBBP
Host Gene: hsa-miR-1291
 
 
 
Disease basic information
DO ID:
 409
DO name: liver disease
Disease details: hepatic fibrosis
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: LX-2 cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1291
Biological function: circCREBBP was significantly down-regulated in primary hepatic stellate cells (HSCs) and liver tissue of HF mice induced by CCl4 compared to those in the vehicle group. Overexpression of circCREBBP with AAV8-circCREBBP_n vivo_revented CCl4-induced HF worsening by reducing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) contents, liver hydroxyproline levels, collagen deposition, and levels of pro-fibrosis genes and pro-inflammatory cytokines. Furthermore,_n vitro_unction loss and function gain analysis showed that circCREBBP inhibited HSCs activation and proliferation.
Molecular mechanism: circCREBBP acts as a sponge for hsa-miR-1291 and subsequently promotes LEFTY2 expression.
Survival: -
Supported No.:
 1
Description:

In conclusion, our current results reveal a novel mechanism by which circCREBBP alleviates liver fibrosis by targeting the hsa-miR-1291/LEFTY2 axis, and also suggest that circCREBBP may be a potential biomarker for heart failure.
Other information
Title:

Circular RNA CREBBP Suppresses Hepatic Fibrosis Via Targeting the hsa-miR-1291/LEFTY2 Axis.

Journal: Front Pharmacol
Published: 2021/12/11
PubMed ID: 34887753