circRNA basic information
circBase ID: -
Name: hsa_circ_EDIL3
Synonym: circEDIL3
Host Gene: hsa-miR-485-3p
 
 
 
Disease basic information
DO ID:
 848
DO name: arthritis
Disease details: arthritis
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human dermal microvascular endothelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PIAS3
Associated microRNA: hsa-miR-485-3p
Biological function: oth SMSCs-Exos and Ad-circEDIL3-SMSCs-Exos significantly downregulated the expression of VEGF induced by the IL-6/sIL-6R complex in the supernatants of RA-FLS and HDMECs co-culture as well as in the cell lysate of co-cultured RA-FLS, and the extent of reduction was more pronounced in the latter.
Molecular mechanism: _ubsequent experiments showed that angiogenic activity was significantly downregulated by SMSCs-Exos and Ad-circEDIL3-SMSCs-Exos due to reduced VEGF expression.
Survival: -
Supported No.:
 1
Description:

The intracellular transfer of circEDIL3 by SMSCs-Exos may be a potential novel therapeutic strategy for RA.
Other information
Title:

Therapeutic Potential of Exosomal circRNA Derived from Synovial Mesenchymal Cells via Targeting circEDIL3/miR-485-3p/PIAS3/STAT3/VEGF Functional Module in Rheumatoid Arthritis.

Journal: Int J Nanomedicine
Published: 2021/12/11
PubMed ID: 34887661