circRNA basic information
circBase ID: -
Name: -
Synonym: N6-methyladenosine circular RNAs
Host Gene: -
 
 
 
Disease basic information
DO ID:
 2913
DO name: acute pancreatitis
Disease details: severe acute pancreatitis
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Fifty-seven circRNAs with differentially expressed m6A peaks were identified by m6A-modified RNA immunoprecipitation sequencing, of which 32 were upregulated and 25 downregulated. Functional analysis of these m6A circRNAs in SAP found some important pathways involved in the pathogenesis of SAP, such as regulation of autophagy and protein digestion.
Molecular mechanism: In m6A circRNA-miRNA networks, several important miRNAs participated in the occurrence and progression of SAP were found to bind to these m6A circRNAs, such as hsa-miR-24-3p, hsa-miR-26a, hsa-miR-92b, hsa-miR-216b, hsa-miR-324-5p and hsa-miR-762. Notably, the total m6A level of circRNAs was reduced, while the demethylase alkylation repair homolog 5 was upregulated in SAP.
Survival: -
Supported No.:
 1
Description:

m6A modification of circRNAs may be involved in the pathogenesis of SAP. Our findings may provide novel insights to explore the possible pathogenetic mechanism of SAP and seek new potential therapeutic targets for SAP.
Other information
Title:

Genome-wide map of N(6)-methyladenosine circular RNAs identified in mice model of severe acute pancreatitis.

Journal: World J Gastroenterol
Published: 2021/12/11
PubMed ID: 34887647