circRNA basic information
circBase ID: -
Name: hsa_circ_USP9X
Synonym: circUSP9X
Host Gene: hsa-miR-148b-3p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: cell line
Sample type details: Human umbilical vein endothelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF5
Associated microRNA: hsa-miR-148b-3p
Biological function: CircUSP9X knockdown inhibited ox-LDL-induced lactate dehydrogenase leakage, apoptosis, inflammation, and oxidative stress in HUVECs.
Molecular mechanism: CircUSP9X directly bound to miR-148b-3p, and KLF5 was a target of miR-148b-3p.
Survival: -
Supported No.:
 2
Description:

In conclusion, circUSP9X knockdown relieved ox-LDL-triggered HUVEC injuries during AS progression partly by mediating the miR-148b-3p/KLF5 network.
Other information
Title:

Knockdown of Circular Ubiquitin-specific Peptidase 9 X-Linked Alleviates Oxidized Low-density Lipoprotein-induced Injuries of Human Umbilical Vein Endothelial Cells by Mediating the miR-148b-3p/KLF5 Signaling Pathway.

Journal: J Cardiovasc Pharmacol
Published: 2021/12/10
PubMed ID: 34882112