circRNA basic information
circBase ID: -
Name: hsa_circ_DOCK1
Synonym: CircDOCK1
Host Gene: hsa-miR-339-3p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteogenic sarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human osteoblastic cell line (hFOB 1.19), human OS cell lines (MG63, SaOS-2, U2OS, HOS)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-339-3p
Biological function: Overexpression of circDOCK1 increased oncogenicity in vivo and malignant transformation in vitro.
Molecular mechanism: In the U2OS and MG63 cell lines, circDOCK1 modulated tumor progression by regulating IGF1R through sponging of hsa-miR-339-3p. Additionally, in the U2OS/DDP and MG63/DDP cell lines, cisplatin sensitivity was regulated by circDOCK1 via the hsa-miR-339-3p/IGF1R axis.
Survival: -
Supported No.:
 4
Description:

CircDOCK1 can promote progression and regulate cisplatin sensitivity in OS via the miR-339-3p/IGF1R axis. Thus, the circDOCK1/miR-339-3p/IGF1R axis may be a key mechanism and therapeutic target in OS.
Other information
Title:

CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis.

Journal: Mol Cancer
Published: 2021/12/9
PubMed ID: 34876132