circRNA basic information
circBase ID: -
Name: hsa_circ_RPPH1
Synonym: circRPPH1
Host Gene: hsa-miR-512-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal breast epithelial cell line (MCF-10A), BC cell lines (MDA-MB-231, MCF-7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-512-5p
Biological function: CircRPPH1 expression was higher in the cancerous tissue compared to paired adjacent tissue. Further in vitro and in vivo experiments indicated that circRPPH1 acted as an oncogene in BC.
Molecular mechanism: circRPPH1 was mainly localized in cytoplasm and played the role of hsa-miR-512-5p sponge. By sequestering hsa-miR-512-5p from the 3-UTR of STAT1, circRPPH1 inhibited the suppressive role of hsa-miR-512-5p, stabilized STAT1 mRNA in BC and finally affected BC progression.
Survival: -
Supported No.:
 9
Description:

these findings indicated that circRPPH1 acted as an oncogene and regulated BC progression via circRPPH1-miR-512-5p-STAT1 axis, which might provide a potential therapeutic target for BC treatment.
Other information
Title:

Circular RNA circRPPH1 promotes breast cancer progression via circRPPH1-miR-512-5p-STAT1 axis.

Journal: Cell Death Discov
Published: 2021/12/8
PubMed ID: 34873163