circRNA basic information
circBase ID: -
Name: hsa_circ_TUBGCP3
Synonym: CircTUBGCP3
Host Gene: hsa-miR-885-3p
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal pulmonary epithelial cells (BEAS-2B), LAC cell lines (A549, NCI-H23, NCI-H1993, SPC-A1, NCI-H460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-885-3p
Biological function: The upregulation of circTUBGCP3 or downregulation of miR-885-3p was associated with the pathological stage and poor survival in patients with LAC. Restored expression of circTUBGCP3 facilitated the growth and invasion of LAC cells, but knockdown of circTUBGCP3 harbored the opposite effects.
Molecular mechanism: In mechanism, circTUBGCP3 could act as a sponge of hsa-miR-885-3p, which suppressed the cell proliferation and colony formation and attenuated the tumor-promoting effects of circTUBGCP3. Wnt10b as a target of hsa-miR-885-3p could be upregulated be circTUBGCP3 and indicate poor survival in patient with LAC.
Survival: -
Supported No.:
 1
Description:

Our findings demonstrated that circTUBGCP3 promoted LAC progression by sponging miR-885-3p, and might represent a prognostic factor for LAC.
Other information
Title:

CircTUBGCP3 facilitates the tumorigenesis of lung adenocarcinoma by sponging miR-885-3p.

Journal: Cancer Cell Int
Published: 2021/12/8
PubMed ID: 34872582