circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: Circ-PVT1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Circ-PVT1 expression was different among AML patients, disease controls and health donors, which was highest in AML patients, followed by disease controls and lowest in health donors.circ-PVT1 could distinguish AML patients from health donors and disease controls by receiver operating characteristic curve analysis. Furthermore, circ-PVT1 was correlated with BM blasts and FLT3-ITD mutation, but not other clinical features, such as French-American-Britain subtypes in AML patients. Moreover, circ-PVT1 expression was lower in AML patients with CR compared with those without CR. Besides, high circ-PVT1 expression was correlated with shorter EFS and OS in AML patients. After adjustment by multivariate Coxs regression analysis, higher circ-PVT1 expression was an independent factor in predicting shorter EFS and OS for AML patients.
Molecular mechanism: -
Survival: poor
Supported No.:
 2
Description:

Circ-PVT1 potentially serves as a biomarker for evaluating the prognosis of AML patients.
Other information
Title:

The role of circular RNA plasmacytoma variant translocation 1 as a biomarker for prognostication of acute myeloid leukemia.

Journal: Hematology
Published: 2021/12/7
PubMed ID: 34871521