circRNA basic information
circBase ID: -
Name: hsa_circ_CRIM1
Synonym: CircCRIM1
Host Gene: hsa-miR-378a-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-378a-3p
Biological function: circCRIM1 was up-regulated in HCC and its expression level was significantly associated with poor prognosis and clinicopathologic characteristics. CircCRIM1 enhanced the proliferation and angiogenesis of HCC cells_n vitro_nd promoted xenograft growth_n vivo.
Molecular mechanism: circCRIM1 upregulated the expression of SKP2 by functioning as a sponge for hsa-miR-378a-3p.
Survival: poor
Supported No.:
 2
Description:

circCRIM1 boosts the HCC progression via the miR-378-3p/SKP2 axis and may act as a crucial epigenetic therapeutic molecule target in HCC.
Other information
Title:

CircCRIM1 Promotes Hepatocellular Carcinoma Proliferation and Angiogenesis by Sponging miR-378a-3p and Regulating SKP2 Expression.

Journal: Front Cell Dev Biol
Published: 2021/12/7
PubMed ID: 34869393