circRNA basic information
circBase ID: -
Name: hsa_circ_RAB3IP
Synonym: circRAB3IP
Host Gene: hsa-miR-133a-3p, hsa-miR-133b
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: 22Rv1 cell lines, PCa cell lines (C4-2, C4-2-EnzR, LNCaP, LNCaP-EnzR)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: miR-133b
Associated microRNA: hsa-miR-133a-3p, hsa-miR-133b
Biological function: circRAB3IP Promotes Enzalutamide Resistance in PCa Cells
Molecular mechanism: circRAB3IP Directly Binds to hsa-miR-133a-3p and hsa-miR-133b in PCa Cells, SGK1 Is a Direct Target of hsa-miR-133a-3p/hsa-miR-133b in PCa Cells, eIF4A3 and LEF1 Promote circRAB3IP Expression
Survival: -
Supported No.:
 1
Description:

circRAB3IP partially exerted its biological functions_ia_GK1 signaling. Furthermore, we discovered that eIF4A3 and LEF1 might increase circRAB3IP expression in PCa.
Other information
Title:

The circRAB3IP Mediated by eIF4A3 and LEF1 Contributes to Enzalutamide Resistance in Prostate Cancer by Targeting miR-133a-3p/miR-133b/SGK1 Pathway.

Journal: Front Oncol
Published: 2021/12/7
PubMed ID: 34868959