circRNA basic information
circBase ID: -
Name: hsa_circ_NUP98
Synonym: CircNUP98
Host Gene: hsa-miR-519a-3p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: U87, U-251
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-519a-3p
Biological function: The role of circNUP98 and miR-519a-3p in GB cell proliferation was explored by 5-bromo-2-deoxyuridine (BrdU) assay and was assessed in mouse xenograft model. Heatmap analysis showed that circNUP98 and pre-mature miR-519a-3p were upregulated in GB, while mature miR-519a-3p was downregulated in GB
Molecular mechanism: circNUP98 was inversely correlated with mature hsa-miR-519a-3p, but positively correlated with pre-mature hsa-miR-519a-3p. In GB cells, circNUP98 was localized to both the nucleus and cytoplasm and it interacted with pre-mature hsa-miR-519a-3p. In GB cells, circNUP98 increased the expression levels of pre-mature hsa-miR-519a-3p and decreased the expression levels of mature hsa-miR-519a-3p. BrdU and cholecystokinin octapeptide (CCK-8) assays illustrated that overexpression of circNUP98 reduced the inhibitory effects of hsa-miR-519a-3p on cell proliferation.
Survival: -
Supported No.:
 1
Description:

CircNUP98 contributed to larger tumors, which resulted in significantly reduced mice survival. CircNUP98 suppresses the maturation of miR-519a-3p to promote GB cell proliferation.
Other information
Title:

CircNUP98 Suppresses the Maturation of miR-519a-3p in Glioblastoma.

Journal: Front Neurol
Published: 2021/12/7
PubMed ID: 34867700