circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circ_007293
Host Gene: hsa-miR-653-5p
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PTC cell lines (TPC-1, KTC-1) were obtained from Procell (Wuhan, China). human thyroid follicular epithelial cell line (Nthy-ori3-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-653-5p
Biological function: Results showed that circ007293 was enriched in exosomes derived from PTC patient serum and cell culture media. Moreover, circ007293 could enter PTC cells through exosomes, and exosomal circ007293 promoted PTC cell epithelial-mesenchymal transition, invasion, migration, and proliferation. circ007293 knockdown reversed the malignant phenotype of PTC cells_n vitro.
Molecular mechanism: circ007293 could competitively bind with hsa-miR-653-5p to regulate PAX6 expression. Notably, hsa-miR-653-5p overexpression or PAX6 inhibition suppressed the malignant effects of exosomal circ007293.
Survival: -
Supported No.:
 1
Description:

These results evidenced that exosomal circ007293 induced EMT and augmented the invasive and migratory abilities of PTC cells via the miR-653-5p/PAX6 axis, suggesting that it may serve as a promising biomarker for cancer progression.
Other information
Title:

Exosomal circular RNA hsa_circ_007293 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through regulation of the microRNA-653-5p/paired box 6 axis.

Journal: Bioengineered
Published: 2021/12/7
PubMed ID: 34866540