circRNA basic information
circBase ID: -
Name: hsa_circ_UBAP2
Synonym: -
Host Gene: hsa-miR-143
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: osteosarcoma cells (MG63, U2OS)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: Bcl-2
Associated microRNA: hsa-miR-143
Biological function: -
Molecular mechanism: circUBAP2 was found to inhibit the expression of microRNA-143 (hsa-miR-143), thus enhancing the expression and function of anti-apoptotic Bcl-2.
Survival: -
Supported No.:
 5
Description:

Increased circUBAP2 could promote osteosarcoma growth and inhibit apoptosis both in vitro and in vivo. Our results suggest the roles of circUBAP2 in osteosarcoma development and implicate its potential in prognosis prediction and cancer therapy.
Other information
Title:

Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.

Journal: Oncotarget
Published: 2017/10/6
PubMed ID: 28977896